SUBJECT: Chronic Lyme Disease and Long-Term Antibiotic Treatment.
Persons planning to attend the public hearing on Lyme
Disease and antibiotic treatment
are requested to complete this reply form as soon as possible and mail or fax it to:
Assembly Member Gottfried's office
822 Legislative Office Building
Albany, NY 12248
Fax: +1 518-455-5939
[X] I do not plan to attend the public hearing but I wish to submit a written statement if I may do so.
[ ] I will require assistance and/or handicapped accessibility
information. Please specify
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TITLE: Dr. rer.nat.
I wish to express my opinion that long-term antibiotic treatment is scientifically sound and has been beneficial to victims of Lyme disease. For decades an analogous approach has been applied successfully in other areas of medicine, e.g. in virus infections such as AIDS and in cancer intervention .
I am a German physicist, cooperating with medical professionals in Europe and the US. About 30 medical professionals who participated in one of my seminars at Leiden University Medical Center, Leiden, The Netherlands, in March 1999 agreed on the following mechanism possibly responsible for symptom cycles in chronic Lyme:
"Some cell wall constituents released by Borrelia burgdorferi (the organism causing Lyme disease), such as lipopolysaccharides, belong to the class of TI-1 antigens. After successful elimination of TI-1 antigens, each new encounter with them produces an immune response identical to the preceding one, i.e. there is no immune memory of a previous encounter. This might lead to a chain of periodic immune responses that continues as long as there is a persistent source of antigen in the host."It has been shown that B. burgdorferi has developed strategies to survive the attack of the immune system and of antibiotics in what might be called "generalized niches" [e.g. 2, 3, 4, 5]. Any such niche might act as the mentioned source in chronic Lyme.
Thus, like in other areas of medicine, an intervention that clinically monitors patients' reactions and adjusts therapy accordingly is likely to be more effective than the "one size fits all" standard approach - advocated in Lyme by the scientific advisors of the OPMC .