Inflammatory Response

by Michael Shih

Inflammatory Response

Figure constructed using Janis Kuby, Immunology (3rd ed.), Figure 13-4

Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions.

Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response.

Macrophages and other phagocytotic cells provide a front-line defense against bacterial infection.

Macrophages stimulate the inflammatory responses of

in response infection by secreting IL-1 and TNF.

Macrophages also present antigen to T helper cells that play a central role in coordinating immune responses.​​

In addition to inducing activation and proliferation of specific differentiated immune cells, cytokines act on hematopoeitic stem cells, causing their proliferation and differentiation into the full range of immune cells.

For pahtways click BioCharta Pathways or here (MacOS WebArchive)

Version: 22 February 2016

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Joachim Gruber