The inflammatory B-cell response in the CSF in response to the CNS infection.

1. Borrelia are recognized by monocytic cells,
2. which produce the B-cell–attracting chemokine CXCL13.
3. B cells immigrate into the CSF
4. and mature to plasma cells.
5. These plasma cells can produce Bb-specific antibodies
6. that can eventually destroy the invaded spirochetes.