Home -- Symptoms -- Cycles -- Mechanisms of Inflammation: Immune Response
| PROCESSES | AUTHORS |
YEAR |
| A role for IL-1 in the pathogenesis of Lyme disease. |
Beck, Habicht, Benach et al. (Stony Brook) |
1986 |
| Cytokines and the pathogenesis of neuroborreliosis: Bb induces glioma cells to secrete IL-6. | Habicht, Katona, Benach (Stony Brook) |
1991 |
Bb induced TNF-alpha:
|
Defosse, Johnson (Minneapolis) | 1992 |
| B cells may amplify T cell responses by recruiting T cells to regions with minute amounts of Bb antigens. | Goronzy, Hanson, Weyand (Rochester) | 1992 |
Bb Osp A and Osp B possess B-cell mitogenic and cytokine-stimulatory properties:
|
Tai, Ma, Weis (Salt Lake City) |
1993/4 |
| Bb increases IL-6 production by fibroblasts. | Jones, Germain, Riley et al. (Tampa) | 1994 |
| Bb OspA induces nuclear translocation of NF-kappa B and inflammatory activation in HEC. |
Wooten, Modur, McIntyre, Weis (Salt Lake City) | 1996 |
| Bb Osp (lipoprotein) activate vascular endothelium in vitro. |
Sellati, Abrescia, Radolf, Furie (Stony Brook) |
1996 |
| Induction of IL-6 by Bb in different cell cultures. | Ponte et al. (Madrid) | 1997 |
| Induction of IL-6 by lipoprotein that is released by growing bacteria. | Zhang et al. (Galveston) | 1997 |
| Levels of endogenous IL-1, IL-6, and TNF- alpha in congenic mice infected with Borrelia garinii. |
Isogai, Kimura, Hayashi et al. (Hokkaido) |
1997 |
| Humoral immunity apparently plays the greatest role in clearance of the organism. |
Hu, Klempner (Boston) |
1997 |
| Bb induced production of IL-8 by cultured EC occurs independently of secreted IL-1 and TNF-alpha and is required for transendothelial migration of neutrophils (Bb). | Burns, Sellati, Teng, Furie (Stony Brook) | 1997 |
| Osp induced production of IL-1b, IL-6 and TNF-alpha in a concentration-dependent manner with peak levels at 12-24 h. | Häupl et al. (Berlin) | 1997 |
| Bb/Osp induced production of IL-1, IL-8, TNF in synovial explant cultures within hours after challenged by untreated, sonicated or 16 h UV-irradiated Bb. | Straubinger, Summers, Erb et al. (Cornell) | 1998 |
| Bb induced production of IL-10 in human periph. blood monon. cells | Giambartolomei et al. (Covington, LA) | 1998 |
| Although much progress has been made in the characterization of the organism, spirochetal factors responsible for infectivity, immune evasion, and disease pathogenesis remain largely obscure. | Hanson et al. (Gaithersburg, MD) | 1998 |