Home -- Symptoms -- Cycles -- Mechanisms of Inflammation: Immune Response
|A role for IL-1 in the pathogenesis of Lyme disease.
||Beck, Habicht, Benach et al. (Stony Brook)
|Cytokines and the pathogenesis of neuroborreliosis: Bb induces glioma cells to secrete IL-6.||Habicht, Katona, Benach (Stony Brook)
|Bb induced TNF-alpha:
||Defosse, Johnson (Minneapolis)||1992|
|B cells may amplify T cell responses by recruiting T cells to regions with minute amounts of Bb antigens.||Goronzy, Hanson, Weyand (Rochester)||1992|
|Bb Osp A and Osp B possess B-cell mitogenic and cytokine-stimulatory properties:
||Tai, Ma, Weis (Salt Lake City)
|Bb increases IL-6 production by fibroblasts.||Jones, Germain, Riley et al. (Tampa)||1994|
|Bb OspA induces nuclear translocation of NF-kappa B and inflammatory activation in HEC.
||Wooten, Modur, McIntyre, Weis (Salt Lake City)||1996|
|Bb Osp (lipoprotein) activate vascular endothelium in vitro.
||Sellati, Abrescia, Radolf, Furie (Stony Brook)
|Induction of IL-6 by Bb in different cell cultures.||Ponte et al. (Madrid)||1997|
|Induction of IL-6 by lipoprotein that is released by growing bacteria.||Zhang et al. (Galveston)||1997|
|Levels of endogenous IL-1, IL-6, and TNF- alpha in congenic mice infected with Borrelia garinii.
||Isogai, Kimura, Hayashi et al. (Hokkaido)
|Humoral immunity apparently plays the greatest role in clearance of the organism.
||Hu, Klempner (Boston)
|Bb induced production of IL-8 by cultured EC occurs independently of secreted IL-1 and TNF-alpha and is required for transendothelial migration of neutrophils (Bb).||Burns, Sellati, Teng, Furie (Stony Brook)||1997|
|Osp induced production of IL-1b, IL-6 and TNF-alpha in a concentration-dependent manner with peak levels at 12-24 h.||Häupl et al. (Berlin)||1997|
|Bb/Osp induced production of IL-1, IL-8, TNF in synovial explant cultures within hours after challenged by untreated, sonicated or 16 h UV-irradiated Bb.||Straubinger, Summers, Erb et al. (Cornell)||1998|
|Bb induced production of IL-10 in human periph. blood monon. cells||Giambartolomei et al. (Covington, LA)||1998|
|Although much progress has been made in the characterization of the organism, spirochetal factors responsible for infectivity, immune evasion, and disease pathogenesis remain largely obscure.||Hanson et al. (Gaithersburg, MD)||1998|