Home -- Symptoms -- Cycles -- Intracellular Locations of Borrelia burgdorferi
(see also "Demonstrating the Intracellularity of B.burgdorferi"
- A compilation by Harold Smith
MD)
| PROCESSES | AUTHORS | YEAR
|
| Only live Bb invaded cultured endothelial cells. | Comstock, Thomas (Winston - Salem) | 1991 |
| Intracellular
localization of Borrelia burgdorferi within human endothelial cells.
200 ... 5000 Bb per HUVEC -> intracellular localization of 10 ... 25% of Bb in 24 h. |
Ma, Sturrock, Weis (Salt Lake City) | 1991 |
| Invasion of human
skin fibroblasts by Bb.
Bb eliminated from the cell surface by ceftriaxone (1 mg/mL = 10-20 x MBC) for 5 days, residual live Bb in perinuclear region. |
Klempner, Noring, Rogers, Georgilis, Peacocke (Boston) | 1992/3 |
| Persistence of Bb in human ligamentous tissue. | Häupl, Hahn, Rittig, Krause et al. (Erlangen/Nürnberg) | 1993 |
| First isolation
of Bb from an iris biopsy
4 patients IgG+/IgM- , 2 patients IgG-/IgM-. |
Preac-Mursic, Pfister, Spiegel (München) | 1993 |
| The fate of Bb
in mouse macrophages: destruction, survival, recovery.
reculturing of Bb from macrophages. |
Montgomery, Nathanson, Malawista (Yale, New Haven) | 1993 |
| Localization of
Borrelia burgdorferi in murine Lyme borreliosis by electron microscopy.
Spirochetes were generally not in or near areas of inflammation. 3 locations in hearts:
|
Pachner, Basta, Delaney, Hulinska (Natl. Inst. Public Health, Prague, Czech Republic) | 1995 |
| Ultrastruct. demonstr.
of Bb antigens in synovial fluid and membrane in chronic LD.
Perivascular areas, deep synovial stroma among collagen bundles, in vacuoles of fibroblasts in SM, and in cytophagosomes of mononuclear cells in SF cell samples. |
Nanagara, Duray, Schumacher Jr (KhonKaen Univ., Thailand) | 1996 |
NOTATION
Bb = Borrelia burgdorferi.
(HUV)EC = (human umbellical vein) endothelial
cells.
LD = Lyme disease.
MBC = minimum bactericidal concentration.
SF = synovial fluid.
SM = synovial membrane.